The DLB at Thirty

Cardiac Sympathetic Neuroimaging in DLB

Researchers in neuroimaging and practitioners who manage patients with dementia may be surprised to learn that imaging of the heart can help distinguish Lewy body disorders from other causes of neurodegeneration. Over the past dozen years, a remarkably consistent neuroimaging literature has emerged indicating that cardiac noradrenergic denervation characterizes Parkinson disease (PD), pure auto...

Yet Another Look at Thirty Categorization Results

We re-analyzed thirty data sets reported in the literature and summarized by Smith and Minda (2000), based on Medin and Schaffer’s (1978) 5-4 structure. In their meta-analysis, Smith and Minda (2000) focused on comparing the prototype and the exemplar model. In our meta-analysis, we applied the varying abstraction model, a multiple-prototype model proposed by Vanpaemel, Storms, and Ons (2005), ...

Coevolution theory of the genetic code at age thirty.

The coevolution theory of the genetic code, which postulates that prebiotic synthesis was an inadequate source of all twenty protein amino acids, and therefore some of them had to be derived from the coevolving pathways of amino acid biosynthesis, has been assessed in the light of the discoveries of the past three decades. Its four fundamental tenets regarding the essentiality of amino acid bio...

Thirty Cases of Pneumonia Amongst the XVth Sikhs at Delhi

Adjunct zonisamide to levodopa for DLB parkinsonism

OBJECTIVE To investigate the efficacy and safety of zonisamide as an adjunct to levodopa therapy for parkinsonism in patients with dementia with Lewy bodies (DLB). METHODS This phase 2, placebo-controlled, randomized, double-blind study consisted of run-in (placebo, 4 weeks) and treatment (placebo or zonisamide 25 or 50 mg once daily, 12 weeks) periods. Outpatients diagnosed with probable DLB...